Peak bagging for peptide mass fingerprinting
نویسندگان
چکیده
منابع مشابه
Peak bagging for peptide mass fingerprinting
MOTIVATION Mass Spectrometry (MS)-based protein identification via peptide mass fingerprinting (PMF) is a key component in high-throughput proteome research. While PMF was the first commonly used protein identification method, provided higher throughput than the tandem MS-based method, its accuracy is lower than that of the tandem MS method. Thus, it is desirable to develop PMF-based algorithm ...
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Identification of proteins by mass spectrometry (MS) is an essential step in proteomic studies and is typically accomplished by either peptide mass fingerprinting (PMF) or amino acid sequencing of the peptide. Although sequence information from MS/MS analysis can be used to validate PMF-based protein identification, it may not be practical when analyzing a large number of proteins and when high...
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In current proteome research, the most widely used method for protein mixture identification is probably peptide sequencing. Peptide sequencing is based on tandem mass spectrometry (MS/MS) data. The disadvantage is that MS/MS data only sequences a limited number of peptides and leaves many more peptides uncovered. Peptide mass fingerprinting (PMF) has been widely used to identify single purifie...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btn123